Pain is always a hot topic – and many underestimate the power of NSAIDs (non-steroidal anti-inflammatories), my personal fav being naproxen. When you are having a sickle cell crisis, your body is in a pro-inflammatory state, so taking medications like naproxen actually address one of the causes of your pain. Opioids are definitely stronger analgesics (aka pain medication) however they just put a bandaid on your pain and don’t actually treat the cause. You can also consider medications that address neuropathic (nerve) pain. Speak to your provider to come up with the best pain management regimen for you!